Mixer loaf much different than hand mixed loaf.

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I know that it would be different but doing it really made me see what people had been talking about.

Going back to My Daily Bread (linked on sidebar) I had previously been doing all of the initial mixing by hand.  Yesterday I decided to bring out the mixer for the first time in a while and try it with the bread hook.  The final dough felt much lighter and softer.  The final baked bread had a much more even consitency and wasn't filled with the holes baked bread sometimes has.

I know one is mechanical and makes things even while my hands might not be as exact as a mixer, but what else causes such a big difference in the final product?